Skip links
Shop
MyOraguard
scroll
Oraguard

Science
Gum Health

This is where we unpack the science behind that idea. No marketing claims, no oversimplified cause-and-effect. Just a closer look at how nutrition, systemic health and periodontal biology intersect, and what that means for predictable clinical outcomes. Written for clinicians who want the evidence, not just the summary.

The Science

Gum Health

Explore the scientific rationale, mechanisms and evidence behind the Gum Health formulation, from inflammation regulation and the oral microbiome to antioxidant defence, collagen repair and periodontal healing.

Clinically Developed

Gum Health was developed by periodontists to bring targeted nutritional support into periodontal care. The formulation reflects the biology of periodontal healing: regulating the inflammatory response, supporting a healthier oral microbiome, and providing the antioxidant and structural nutrients tissue repair depends on. Built from clinical experience and nutritional science, the protocol was designed to be both biologically relevant and practical for everyday periodontal treatment.

01

Provides Omega-3 fatty acids to help regulate the inflammatory response.

02

Supports a healthier oral microbiome with Lactobacillus reuteri.

03

Provides key antioxidants to help protect tissue against oxidative stress.

04

Supports collagen formation and immune function during tissue repair.

Active ingredients
per daily dose

Hover (or tap) any nutrient for the rationale and clinical evidence behind it.

Tablet · 1 a day

Vitamin A i

Why it’s included

Vitamin A contributes to epithelial integrity, immune function and normal growth and differentiation of periodontal tissues.

Clinical evidence

A 2024 meta-analysis found that higher vitamin A intake/status was associated with better periodontal health, while inadequate intake has repeatedly been associated with greater periodontal disease severity.

Mi et al., 2024 · DOI
Luo et al., 2018 · DOI

 900 µg
Lycopene i

Why it’s included

Lycopene is a powerful dietary antioxidant that may help counter the oxidative stress associated with periodontal inflammation.

Clinical evidence

A 2024 systematic review and meta-analysis of 7 randomized trials found benefits for several periodontal inflammatory outcomes, including short-term pocket depth and bleeding on probing.

López-Valverde et al., 2024 · DOI

 8 mg
Vitamin B9 i

Why it’s included

Folate supports DNA synthesis, cell turnover and tissue repair and contributes to normal homocysteine metabolism.

Clinical evidence

In a randomized placebo-controlled trial, systemic folic acid added to scaling and root planing produced additional improvements in clinical and biochemical periodontal parameters.

Keceli et al., 2020 · DOI

 500 µg
Vitamin B12 i

Why it’s included

Vitamin B12 supports normal cell division, tissue renewal and homocysteine metabolism.

Clinical evidence

In a prospective cohort of 1,648 adults followed for almost 6 years, higher serum vitamin B12 was associated with less periodontal progression and a lower risk of tooth loss.

Zong et al., 2016 · DOI

 25 µg
Vitamin D3 i

Why it’s included

Vitamin D supports immune regulation, antimicrobial defence and normal bone metabolism — all important during periodontal healing.

Clinical evidence

Systematic reviews show that patients with periodontitis tend to have lower vitamin-D levels. Supplementation during periodontal therapy has shown potential benefit, particularly in patients with insufficient vitamin-D status, although clinical evidence remains limited.

Machado et al., 2020 · DOI
Perić et al., 2020 · DOI

 50 µg
Vitamin E i

Why it’s included

Vitamin E is a lipid-soluble antioxidant that helps protect periodontal tissues against oxidative stress.

Clinical evidence

In a randomized clinical trial, adding vitamin E to scaling and root planing resulted in better periodontal healing and improved antioxidant defence compared with periodontal therapy alone.

Singh et al., 2014 · DOI

 39 mg
Magnesium i

Why it’s included

Magnesium contributes to normal bone metabolism, cellular function and antioxidant enzyme activity.

Clinical evidence

Higher magnesium intake has been associated with a lower prevalence of periodontitis; in NHANES data, the highest intake group had approximately 31% lower odds of periodontitis than the lowest. A clinical study also found enhanced antioxidant-enzyme activity when magnesium and zinc were added to periodontal therapy.

Li et al., 2022 · DOI
Alarcón-Moreno et al., 2024 · DOI

 350 mg
Selenium i

Why it’s included

Selenium is required for antioxidant enzymes such as glutathione peroxidase and therefore contributes to protection against oxidative stress.

Clinical evidence

Recent studies show significantly lower selenium levels in patients with periodontitis, supporting a link between selenium status, oxidative stress and periodontal inflammation. Direct supplementation trials are still lacking.

Uytun et al., 2025 · DOI

 60 µg
Zinc i

Why it’s included

Zinc supports immune function, wound healing and antioxidant defence and is required by numerous enzymes involved in tissue repair.

Clinical evidence

Clinical research adding zinc and magnesium to non-surgical periodontal therapy found increased antioxidant enzyme activity alongside improvements in periodontal parameters. More recent clinical studies also support zinc as a potential adjunct in periodontitis management.

Alarcón-Moreno et al., 2024 · DOI
Gupta et al., 2025 · DOI

 10 mg
Lactobacillus Reuteri i

Why it’s included

L. reuteri can help support a healthier oral microbiome and modulate periodontal inflammation.

Clinical evidence

A meta-analysis found that L. reuteri used alongside scaling and root planing produced an additional ~0.40 mm pocket-depth reduction and ~0.30 mm attachment gain at 3 months.

Song et al., 2020 · DOI

 500*10^6 CFU

Syrup · 10 ml a day

Omega-3 fatty acids i

Why it’s included

EPA and DHA help regulate the inflammatory response and support resolution of inflammation.

Clinical evidence

A 2022 systematic review and meta-analysis found that omega-3 supplementation in addition to periodontal therapy improved probing depth and clinical attachment compared with periodontal therapy alone (≈0.4–0.5 mm additional improvement).

Van Ravensteijn et al., 2022 · DOI
Castro dos Santos et al., 2022 · DOI

 2000 mg
Of which DHA 700 mg
Of which EPA 500 mg
Vitamin C i

Why it’s included

Vitamin C is essential for collagen formation and antioxidant defence — key processes in periodontal tissue repair.

Clinical evidence

A systematic review specifically evaluating vitamin C alongside non-surgical periodontal therapy found evidence of improved antioxidant status, and greater BoP reductions.

Fageeh et al., 2021 · DOI

 240 mg
Coenzyme Q10 i

Why it’s included

CoQ10 is essential for cellular energy production and acts as an endogenous antioxidant in metabolically active tissues.

Clinical evidence

Clinical trials have investigated CoQ10 specifically as an adjunct to scaling and root planing, with several reporting additional improvements in probing depth, attachment and gingival inflammation. Recent systematic reviews support a potential adjunctive effect, although study protocols remain heterogeneous.

Merle et al., 2023 · DOI
Fernandez et al., 2025 · DOI

 22.5 mg

Why these nutrients?

Periodontal healing is not a single process. It depends on regulating inflammation, maintaining a healthier balance of oral bacteria, protecting tissue against oxidative stress, and supporting the collagen repair that follows treatment.

Omega-3 fatty acids and Lactobacillus reuteri address the inflammatory and microbial side of periodontal disease, helping regulate the response and support a healthier oral microbiome. Vitamin C, E, A, lycopene, selenium and Coenzyme Q10 provide antioxidant support against the oxidative stress associated with periodontal inflammation.

Vitamin B9, B12, magnesium, zinc and vitamin D support the metabolic and structural side of healing, from cell turnover and homocysteine metabolism to bone metabolism and collagen-dependent tissue repair.

The result is a formulation designed around the different biological requirements of periodontal healing rather than a single isolated nutrient.

Explore
Drag